The Comfort Inn Blacksburg is located on South Main Street, just minutes from the main campus of Virginia Tech (Virginia Polytechnic Institute and State University). With easy access to Interstate 81 and U.S. Highway 460, the hotel is approximately forty minutes from Roanoke Regional Airport.

The Blacksburg Comfort Inn is the affiliate hotel for the Virginia Tech Corporate Research Center and the Virginia College of Osteopathic Medicine, and directly across Main Street from LewisGale Hospital at Montgomery. For full service meals the local favorite El Mariachi Restaurant and Cantina is adjacent to the hotel.

Other nearby attractions includes Smithfield Plantation, Warm Hearth Village, and Heritage Hall Nursing Home. The hotel is convenient to Blacksburg Industrial Park and the downtown business district, as well as a full array of shopping and restaurants at the nearby New River Valley Mall.